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Morphogen-IX – Nick Morell

Morphogen-IX has developed protein-engineered forms of bone morphogenetic protein 9 (BMP9), conferring potent protection of the blood vessels in the lung, whilst lacking the bone-inducing properties of the native protein. BMP9 has shown strong preclinical efficacy in the reversal of PAH.  This approach is based on targeting the central pathway underlying PAH identified in human … Continue reading Morphogen-IX – Nick Morell

Acceleron’s Sotatercept – Granted FDA’s Breakthrough Therapy Status for PAH.

According to the US Food and Drug Association, Breakthrough therapy designation is intended to expedite the development and review of drugs for serious or life-threatening conditions. The criteria for breakthrough therapy designation require preliminary clinical evidence that demonstrates the drug may have substantial improvement on at least one clinically significant endpoint over available therapy. The … Continue reading Acceleron’s Sotatercept – Granted FDA’s Breakthrough Therapy Status for PAH.